SELECT analysis: age, sex and BMI explain little of who loses most weight on semaglutide
_Image credit: Endocrinology Advisor_
A secondary analysis of 7,594 people without diabetes in the SELECT heart trial, published in Diabetes Care, found a median peak weight loss of 12.5% on semaglutide, reached after a median of 19 months. Standard baseline factors such as age, sex, BMI and kidney function explained under 10% of the variation, with women on the 2.4mg dose losing the most (median 16.6%).
Source: Endocrinology Advisor (11 Nov 2026). Image: Endocrinology Advisor.